Important news related to PCA happens frequently. The aim of the links provided is to help inform you of information in the news that is relevant to PCA and PCA-related disorders, such as Alzheimer’s disease or Lewy Body Dementia.
News regarding Alzheimer’s disease vaccine. Recently, news about the use of an Alzheimer’s disease (AD) vaccine has been circulating and I would like to provide information about what the news is about to our PCA Support Group members and others who visit these pages. The journal of Alzheimer’s Research & Therapy published an article in November 2018 regarding animal research of an experimental vaccine for AD and the research was performed at the University of Texas Southwestern Medical Center.
The goal of the vaccine is to create an immune response to the proteins that accumulate in the brains of people with Alzheimer’s disease, which include amyloid and tau. These proteins are not related to the protein in your diet. Instead, these proteins accumulate in the brain of people with AD disease and form the substances that pathologists look for when performing an autopsy to determine whether someone had AD.
The researchers at the University of Texas vaccinated a special breed of mice that carry the mouse-form of AD and found that immunization led to a “reduction” of aggregation and accumulation of both proteins (amyloid and tau). In addition, they found that there was no inflammation that occurred. In the past, a vaccination for AD was given to humans in a clinical trial and unfortunately, brain inflammation resulted and use of the vaccination had to be halted.
In addition to this study, others are also moving forward with ways to use immune-based treatments to help reduce the accumulation of abnormal proteins. Stay tuned for more information. The animal-based studies are the first step toward clinical trials, but for this particular study, the human trial could be several years away. Victoria Pelak, MD
November 27, 2018: UCHealth Today by Tyler Smith: A Brain Disease that Betrays the Eyes – Click Here
October 24, 2018: Rare Form of Alzheimer’s Affects What The Eyes See – CBS News Interview of Dr. Pelak & Robert Yetz: Click Here
October 2018: News from Alzheimer’s research clinical trials conference from October 2018 in Barcelona, Spain. Recent data from the very large and multi-centered IDEAS study, which assessed whether results from PET imaging of amyloid accumulation changes treatment plans and/or impacts costs of care. Read more about it here